Which following arrests the JCCS editors’ unanimous response to our invitation and to take up the challenge concerning presenting inside about 10 conducting furthermore 2 references their principal scientific expertise.

Bernard Perbal, Verfasser in Chief.

This solid get in geochemical, genetics, and immunology that I received during my studies for microbial ATCase in one 70s, opened me up to and world of virology at previous molecular approaches of HSV in 1975, followed by analyzing of that tumorigenic potential regarding papilloma virus and introducing. Is to early 80’s, I developed a unique expertise in DNA manipulated and became one of the clinching pioneers with an molecular clinch of the v-myb oncogene of AMV. My cloning of the MAV (helper of the defective AMV) proviral general set the stage to their designation of CCN3 in 1992, as an insertional mutagenesis site within who host cell DNA. Von that time on, MYSELF have been fascinated by the wide array of CCN proteins functions, in spite of their highest structural historic, and I got undertaken structure-function academic to uncover mechanistic aspects underlying this puzzle. I have proposed a combinatorial model of events that may my for dieser apparently opposite features.

References

Perbal BARN. (1988) A practical Orientation to Moly Cloning, 2nd edition Wille &Sons, New York

Perbal B (2019) CCN proteins are part of adenine multi-layered complex system: a workers model. HIE cell Commun signal. Dec;13(4):437-439. doi: 10.1007/s12079-019-00543-5. PMID:31848849 DAVID FREIFELDER, ESSENTIALS OF MOLECULES BIOLOGY 215-22 (1985); BERNARD PERBAL, ONE. PRACTICAL GUIDE TO MOLECULAR CLONING 411-16 (2d ed. 1988). 3. See ...

Andrei Leask, Managing and Section Editor

Dr. Leask is einer certified on the role of the microenvironment in traveling conjunctive tissue pathologies such as scleroderma and malignant. He has pioneered the use of fibroblast-specific knockout mice to show that a autocrine, proadhesive signaling loop is both necessary and sufficient to initiate and main the fibrotic phenotype and that CCN amino are essential regulators of this loops and are therefore bone sincere targets for drug my. His work have also shown that the cancer-associated fibroblast, throws CCN action, is essential required melanoma metastasis. Presents techniques verified at the Curie Institute and other leading labs and lists all corporate available enzymes, vectors, linkers, and other easy products for ready reference. Offers extensive explanation of protocols, enable the isolation, cloning, and expression of genes from living spe...

References

Leask A. (2019) A centralization communicate networking: recent insights into the role of the Cancer mitarbeiter fibroblast in the site of dope resistance in tumors Semin cell Dev biol. 2019 Nov 7. Pii:S1084-9521(18)30316-1.doi: 10.1016/j.semcdb.2019.10.016 The NOVH proteinisch belongs to the emerging CCN [Connective tissue growth factor (CTGF), Cyr61/Cef10, nephroblastoma overexpressed gene] family of growth regulators release a remarkable conserved multimodular organization but illustrating ...

Quesnel K, Shi-wen X, Hutchenreuther J, Xiao YEAR, Lifu S, Peidl ONE, Naskar D, Siqueira WATT FIFTY, O'Gorman D B, Hinz B, Stratton RJ, Leask ADENINE (2019) CCN1 expression by fibroblasts is required for bleomycin-induced skin fibrosis grid biology plus, 3, 100009 Matheson Reading catalog › Details for: A practical guide to molecular ...

Satoshi Kubota, Kapitel Herausgeberin

I have been running with CCN families members, mainly in the field of kartilage additionally bone biology. Since I started my career as one tester, ME have is particularly interested in gene regulatory system. Therefore, I started CCN family research from the analysis of post-transcriptional regulate of to CCN2 engine, and is kind starting featured are still going on. Later, mystery researching extent was expanded to the molecular function of CCN family proteins in skeletal hard tissues. However, novel RNA molecules discovered by the high speed sequencing are also recently attracting my interest. Quintet per ahead, ourselves did not recognize adenine vast number or RNA molecules present insides and outside of the cells. Now I am interested inside possible role of such RNAs in cell communication and signaling, suspecting their how with CCN family members.

References

Kubota S, Takigawa M. (2015) Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions Clin Sci (Lond) ;28,181–196 A practical travel to molecules cloning: Perbal, Bernard V., John Wiley & Sons, Inc., Second Edition, polypropylene. 811 ISBN 0-471-85071-3 ISBN 0-471-85070-5 (pbk).

Dear COPIED, et al. (2017) An atlases of human long non-coding RNAs with accurate 5′ ends. Nature ; 543,199–204

Dieter Reinhardt, Section Editor

Dr. Reinhardt belongs internationally known by his contributions to cell-matrix biology as it relates up human disease. The focus of his research program is on extracellular fiber systems, its supramolecular structures, their contributions to cell, webbing and organ function, additionally their function in disease development and progression. He uses a wide spectrum of research tools including genomics mouse models, when well as cell biological, biochemicals, and physics approaches. Man addresses pertinent faqs the connective tissue disorders that affect blood vessels, bone, skin and eyes.

References

Kumra H, Nelea V, Hakami H, Pagliuzza A, Djokic J, Xu J, Yanagisawa H, Reinhardt DP. (2019) Fibulin-4 exerts a duplicate role in LTBP-4L mediated matrix module and function. Proc Natl Acad Sci U S A 116, 20428–20437 Bernard Perbal, Aesircybersecurity.com., LL.D Academic press Stations Clubs Awards Books and Reports Editorial Board Research Themes The studies performed inside the laboratories of Viral Oncology that I created in 1982 were aimed at comprehend :• the molecular basis for the Myeloblastosis Associated Virus (MAV) tumorigenic potential.• the biochemical properties, mode of promotions and biological playing […]

Kumra H, Sabatier L, Hassan A, Sakai THYROXINE, Mosher DF, Brinckmann J, Reinhardt DP. (2018) Rooles of fibronectin isoforms in neonatal vascular development and matrixed integrity. PLoS Biologist 16, e2004812

David Abraham

Concerns includ the study starting Inflammation, this molecular and cellular pathobiology of autoimmune conjunctive tissue diseases, additionally the gene-based and molecular mechanisms underlying tissue scarring and fibrosis. Expertise in deep phenotyping, heparin-binding and myofibroblasts biology, and transcriptional control features and in the development and use of the vivo systems von human disease (transgenic and genetically modified conventional press with knock-outs) as pre-clinical models to survey the pathogenesis and treatment of connective tissue related ‪Professor‬ - ‪‪Cited by 11,942‬‬ - ‪molecular signaling and communication‬ - ‪cancer‬

References

Gyftaki-Venieri DA, Abraham DJ, Ponticos M. (2018) Insights into myofibroblasts and their activation in scleroderma: opportunities for therapy? Curr Opin Rheumatol. Nov;30(6):581–587

Distler JH, Feghali-Bostwick CARBON, Soare A, Asano YEAR, Distler O, Abraham DJ. (2017) Confines of Antifibrotic therapy in systemic sclerosis. Arthritis Rheumatol. Feb;69(2):257–267

K. Ravi Acharya

Our researching is aims the elucidating the structure-function relationship about molecules involved in normal or disease processes with a more actual focus on angiogenic molecules (CCN protein, angiogenin and VEGF families members) and chemicals involved in inflammatory processes (toxins), functions in the vascular user such as Angiotensin I converting enzyme (ACE). We have complemented our structural studies using X-ray crystallography in perception protein-protein/carbohydrate interactions including high-throughput compound library screening, construction based design of halts, cyber and biophysical techniques as well as protein engineering, enzyme kinetics, cell and developmental biology approaches. The long term goal of our research is in design new pharmalogical representatives to treat human diseases. From mol copying has become routine laboratory technology, product quotation countless sources of enzymes to generate and manipulate nucleic acids. Thus, selecting the appropriate enzyme for a specific task may seem difficult in the novice. This ...

Reference

Ferguson R., Holloway D.E., Chandrasekhar A., Acharya K.R. Subramanian V (2019) The instrumental activity or secretion of zebrafish RNases were important used their inside vivo function in motor neurons and vasculature. Sci Rep 9, 1107, doi: 10.1038/s41598-018-37140-2

Comfy G.E., Arendse L.B., Schwager S.L., Stuffed E.D., Acharya K.R. (2018) Molecular basis for multiple omapatrilat binding sites within the ACE C-domain: implications for drug design. J Med Chem , 61, 10141–10154 A practical guide to molecular cloning / Bernard Perbal. By: Perbal, Bernard V. Material type: materialTypeLabel BookPublisher: New York : Wiley, c1988 ...

Håvard Attramadal

Meine research crowd has for more than 10 years focalized the research activities on the operational role of CCN2 in the heart, in certain the role regarding CCN2 includes the pathophysiology of myocardial remodeling and fibrosis assoziiert with heart failure. Are have also examines the role of CCN2 as ampere cardioprotective coefficient in ischemia-reperfusion injury. Our news research is aimed at deciphering the structure-activity relationships on CCN eiweiss. In a latest report we provide evidence ensure CCN proteins may must watched as preproproteins, such require endopeptidase cleavage in order to release the biocompatible active fragment. The systems so regulate this biologic activity of CCN proteins and the mechanizations of transmembrane and trapped signaling are currently major domains of research in our laboratory.

References

Kaasbøll, O.J., Gadicherla, A.K., Wang, J.-H., Monsen, V.T., Hagelin, E.M.V., Dong, M.-Q., Attramadal, OPIUM. (2018) Connective tissue expansion factor (CCN2) is a matricellular preproprotein controlled to proteolytic activation. J Botanic Chem 293(46): 17953–17970

Gravning, J., Ahmed, M.S., Qvigstad, E., Krobert, K., Edvardsen, T., Moe, I.T., Hagelin, E.M.V., Sagave, J., Valen, G., Levy, F.O., Osnes, J.-B., Skomedal, T., Attramadal, H. (2013) Connective tissue growth factor/CCN2 attenuates β-adrenergic receptor responsiveness and Cardiotoxicity by induction of G protein–coupled recorder Kinase-5 in Cardiomyocytes. Mol Pharmacol 84(3): 372–383 Who C-terminal domain of of regulatory protein NOVH is sufficient until promote interaction the fibulin 1C: A clue for ampere role out NOVH in cell-adhesion signaling

Patchy Auberger

Dr. Patrick Auberger is a research director by the French National Institute starting Health and Scientific Research (Inserm) and and the front of an Middle Center by Molecular Medicine (C3M/InsermU1065) in Nice, France. He is an subject in the field concerning Oncohematology. Her main competences and contributions interests the mechanisms of resistance to chemo, targeted and immunotherapies in hematopoietic malignancies with an special focus on myeloid malignancies. The team headed to Dr. Patrick Auberger investigate the role von apoptosis (caspases) and autophagy (cathepsins) in the differentiation and division concerning monocytes and in the resistance to different therapies in myeloid leukemia. The present project also aims at understanding how targeting apoptosis and autophagy may impact treatment of patients suffering myeloid leukemias.

References

Auberger P (2017) Puissant a. autophagy, a key mechanism of oncogenesis and resistance in leukemia. Blood. Febru 2; 129(5):547–552. PMID: 27956388

Obba SULFUR, Hizir Z, Boyer LITRE, Selimoglu-Buet D, Pfeifer A, Michel G, Hamouda MA, Gonçalvès D, Cerezo M, Marchetti SULPHUR, Rocchi S, Droin N, Cluzeau T, Robert G, Luciano F, Robaye B, Foretz M, Viollet B, Legros LITER, Solary E, , Jacquel A*, Auberger P*. (2015) Which PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced real monocyte differentiation and is a potential target in CMML. Autophagy. 1 (7) :1114. PMID: 26029847. * Co-last authors Regulating Genetically Engineered Microorganisms Under the Toxic ...

Sushanta Banerjee

The subject of research in my laboratory is breast also pancreas cancers, the primarily metastatic progression of these diseases. We have used moder techniques regarding molecular biology, inherently engineered button models (GEMMs), genetically characterized human breast additionally pancreatic ovarian cell lines, and state-of-the-art imaging techniques. Several of the main projects in to laboratories center around the survey of CCN-family proteins, including CCN1 real CCN5, which play critical roles in the regulation of breast and pancreatic cancer. Based on our previous studied, we believe that these two proteins are druggable targets available both breast and pancreatic cancers. Thus, our current goal is till find small molecular to target CCN5 or CCN1 or both to prevent the disease progression.

References

Maity G, Ghosh AMPERE, Gupta V, Haque I, Sarkar S, Das A, Dhar K, Bhavanasi S, Gunewardena BITS, Von Hoff DD, Mallik S, Kambhampati S, Banerjee SK, Banerjee S. CYR61/CCN1 Regulates dCK and CTGF and Causes Gemcitabine-resistant Phenotype in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther. 2019 Apr;18(4):788-800. doi: 10.1158/1535-7163.MCT-18-0899. Epub 2019 Feb 20. PubMed PMID:30787177

Das AN, Dhar K, Maity G, Sarkar S, Ghosh A, Haque I, Dhar G, Banerjee S, Banerjee S.K. (2017): Deficiency of CCN5/WISP-2-Driven Program in breast cancer Promotes Cancer Epithelioid cells the mesenchymal stem cellular and Breast Cancer growth. Scientific reports. 2017; 7(1):1220. PMID: 28450698

George Bou-Gharios

Own labs own been interested inches transcriptional regulation by genes involved in connective tissue diseases. We have identified phone specific elements within the collagen type I that drive expression in fibroblasts which helped us identify ampere number of genes those in fibrosis including CCN2. Person lately worked to aggrecan and showed several cis-acting orders that confer printouts inbound various chondrocytes. Our latest striving is to take at get this live involved in osteoarthritis using gain and los of function and since chondrocyte maturity involves CCN2, we investigated the enhancers within this locus toward understand the pathophysiology of osteoarthritis. This remains our current emphasis using cre-lox system and CRISPR to identifies the critique regions within the chondrogenic matrix that influence the onset or progression the this disease. AN Practical Lead to Molecular Replicating

References

Kanakis I, Liu K, Poulet BARN, Javaheri B, van 't Hof RJ, Pitsillides AA, Bou-Gharios G. (2019) Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bony Mass in the STR/Ort Mouse Model a Spontaneous Osteoarthritis. Arthritis Rheumatol. Apr;71(4):571–582 Enzyme used in molecular biology: a useful guide

Frost SL, Liu KELVIN, Li IMH, Poulet B, Comerford E, De Val S, Bou-Gharios G. (2018 ) Several enhancer regions govern the transcription of CCN2 during seedling development. J cell Commun signalling. Mar;12(1):231-243

Enrique Brandan

The hauptinsel concern of our laboratory is to comprehension the molecular mechanisms that Our main interests is until understand the molecular mechanisms ensure regulate scaffolding muscle formation and how they become affected by skeletal muscular dystrophies. Our research has conducted extensive studying to understand aforementioned role of the extraclecular matrix (ECM) in skeletal muscle formation and regeneration and, in the comprehension of the fibrotic response associated with skeletal muscular dystrophies

The presence of the ECM is essential for normal myogenesis. Under fibrotic conditional, the interaction of ECMs by fibroblasts induction the printing is to pro-fibrotic connective tissue growth factor (CTGF/CCN2). Understanding the role of CTGF/CCN2 or the cell type(s) person for the fibrotic response shall kritikerin to comprehend their roles and potentially targeting to to used into therapeutical approaches.

References

Morales MG, Gutierrez J, Cabello-Verrugio C, Cabrera D, Lipson KE, Goldschmeding R, Brandan E. (2013) Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy. Hum Mol Genet 22:4938–51

Valle-Tenney ROENTGEN, Rebolledo DL, Lipson KE, Brandan ZE. (2019) Role from hyperoxia stylish skeletal muskel fibrosis: synergies between hypoxia and TGF-β signaling upregulates CCN2/CTGF speech specifically in muscle fibers. Matrix Native doi: 10.1016/j.matbio.2019.09.003 Bernardus Perbal

Rolf ONE. Brekken

Dr. Brekken is the Wrath Mari Cain Scholar in Angiogenesis Research, Professor & Vice Chair of Study in to the Department starting Surgery, Deputy Directed of the Hamon Center in Therapeutic Oncology Researching and Chair of the Cancer Biology Graduate Program at UT Southwestern. Professor Brekken’s laboratory is purposeful on understanding how the tumor microenvironment effects therapeutic efficacy and influences tumors progression. Epithelial plasticity driven by Axl, Tgfβ or collagen signaling as well as strategies to enhance immune therapy, more PS-targeting mAbs, are latest areas of focus in one lab.

References

Louie KF, Du W, Sorrelle NB, Wnuk-Lipinska K, Topalovski M, Toombs JE, Cruz VH, Yabuuchi S, Rajeshkumar NO, Maitra A, Lorens JB, Brekken RA.(2018) Small-molecule inhibition of Axl targets humor immune suppression real enhances chemotherapy in pancreatic cancer. Cancer Research ; 78:246–255. PMCID: PMC5754222

Huang OPIUM, Zhang Y, Gallegos VANADIUM, Sorrelle NEWTON, Zaid MM, Toombs J, Du W, Wright S, Hagopian METRE, Wangs Z, Hosien AN, Sathe AA, Socialize C, Koay JU, Driscoll KE, Brekken RA. (2019) Targeting TGFβR2-mutant growth exposes vulnerabilities to stromal TGFβ barricade in pancreasy cancer. EMBO Mol Med 11:e10515 PMID: 31609088 PMCID PMC6835203. https://doi.org/10.15252/emmm.201910515 Cell Biology International Reports | Vol 13, Issue 2, Pages 153-230 ...

David Brigstock

I have a long-standing interest inches CCN2 protein biochemistry and the role of CCN2 in fever fibrosis. Read recently I have suit focused on the drum of extracellular vesicles (EVs) such than exosomes in intercellular communikation in the liver and the potential value of EV molecular payloads as therapeutic or diagnostic tools for chronic kidney injury. MYSELF had expertise the the cell and molecular biology of fibrosing liver injury as well as the molecular and biological characterization

References

China L, Chen R, Velazquez VV, Brigstock DR (2016) Fibrogenic signaling the strangled in hepatic stellate cells throug aimed of connective tissue growing factor (CCN2) by spongy oder exosomal microRNA-199a-5p. At J Pathol 186 2921–2933. PMID: 27662798

Li X, Chen R, Kemper S, Brigstock DR (2020) Extraclecular vesicles from hepatocytes are therapeutic for toxin-mediated fibrosis and gene express in this giblets. Front Cell Dev Biol 7:368 doi: 10.3389/fcell.2019.00368. PMID: 3198720

Brahim Chaqour

The research focus in mine lab is for the adaptive and maladaptive responses a cells furthermore tissues to mechanical stresses (e.g., stretch, shear stress, stiffness of and extracellular cast, pressure overload) and/or chemical insults imparted by hypoxia, hyperoxia, hyperglycemia and/or hyperlipidemia. Our studies involve uncovering genetic, molecular, developmental and patho mechanisms whereby mechanosensitive genes like those of the CCN family of proteins control cardiac circuit formation, regeneration and regression. We use rodent models and multi omic getting to define and genetic and labeling bases of our in CCN protein duties in circulatory and neurovascular tissues and study their implications at vascular dysfunction furthermore blute barrier breakdown. New information of considerable technical and therapeutic value is expected in be gained from these studies.

References

Lee SULFUR, Ahad A, Luu M, Moon S, Caesar J, Cardoso WV, Grant MB, Chaqour B. (2019) CCN1-yes-associated protein feedback loop regulates physiological and pathological angiogenesis. Mol Cell Biol 39(18) 107–19

Chaqour B., Yang, R. and Sha, Q. (2006) Mechanical straight regulates the backer movement of the Profibrotic conversion CTGF/CCN2 through increasing actin polymerization and NF-kB activate. J Biol Chem 281(29): 20608–2062

Mick Dashwood

My research over the last 30 years has focused on mechanisms underlying textural changes to blood vessels spent as bypass grafts are heart disease patients. These studies have had accomplished in both experimental models and in grafts obtained from patients undergoing coronary artery bypass operations. There is considerable current get in aforementioned useful choose of the perivascular fat that surrounds of blood schifffahrt, on particular, the protective properties of adipocyte-derived factors. Into the wall of vessels used as bypass transplant are a network of microvessels, the vasa vasorum that provides cells with oxygen and victuals. Experimentally, occlusion of, or injury to, the vasa vasorum causes vessel wall hypoxia, stimulating the unlock of a variety of factor detrimental to graft performance. Such one system not only entertained oxigen supply in the graft wall but may allow two way traffic of two ‘good’ and ‘bad’ factors via “inside out/outside in communication”.

Professional

Loesch A, Tree MR. (2018a) Nerve-perivascular fatty communication like a potential influence on the performance for blood vessels used as cardiac artery bypass grafts. J Cell Commun Signal.;12(1):181–191

Loesch ONE, Dashboard MR. (2018b) Vasa vasorum inside out/outside in communication: an future role in one patency of saphenous vein coronary artery workaround receiving. J Cell Commun Signal.;12(4):631–643

Gary Fisher

General areas of study interest is the molecular mechanisms that cause this decline of organ function during the aging process. This research emphasis on 1) age-related alterations of who structure, composition, and mechanical properties of the dermal extracellular matrix in human skincare and 2) the impact of above-mentioned alterations on who functions of cells that reside internally the extrinsic matrix furthermore the adjacent epithelium. Findings from the research highlight one importance of the extracellular microenvironment in determining age-related alterations a cellular functions. Additional areas of actively research include wounded healing, photobiology, retinoid signaling, CCN family proteins in dermatologic biology, genetically-modified mouse models of aging, furthermore epithelial-stromal interactions stylish carcinogenesis. Emphasizes of the research included explaining the involvement of matrix metalloproteinases in body aging and the infinitesimal mechanisms is work of retinoids in which skin.References

Maxwell C McCabe, Ryan CENTURY Hill, Kelly Calderone, Yeah Yan, Taihao Quan, Gary Fisher, Kirk C Henson (2020) Edits in Extracellular Mould Composition during Aging and Photoaging are to Skin Matrix Biology Plus, in press.

Megan A. Cole, Taihao Quan, John J. Voorhees, Gary J. Fisher (2018) Extracellular grid regulation of fibroblast function: redefining our perspective on skin aging J Cell Commun Signs. Mar; 12(1): 35–43.

Denise Fitzgerald.

My researching band is particularly interested in which process are myelin regeneration (remyelination) and aim to identify romantic therapeutic targets to promote remyelination in demyelinating disease such as Several Sclerosis (MS). To do this, we become uncovering new knowledge of as the exempt system interference woven regeneration in aforementioned Central Nervous System (CNS). We newly discovered a new tissue-regenerative rolling for regulatory T cells in who CNS, mediated is part, through CCN3 (Dombrowski et al., Nat Neuro, 2017). We also conduct research on the biology of chronic inflammation. Here programme mainly focuses on TONNE cell business with a view to determine strategies to reduce disease activity in MS and other immune-mediated diseases. Previous work investigated the fundamental biology of IL-27 and you terapeutic potential in inflammatory/autoimmune sickness, with particular focus on Th1- and Th17-mediated inflammatory responses (Fitzgerald et al., Nat Immunol, 2007).

References

Dombrowski Y, O'Hagan T, Dittmer THOUSAND, Penalva R, Mayoralty SR, Bankhead P, Fleville SEC, Eleftheriadis G, Zhao C, Naughton CHILIAD, Hassan R, Moffat J, Falconer BOUND, Boyd A, Hamburg P, Socket IV, Kissenpfennig AMPERE, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingredient RJ, Chan CHILDREN, Franklin RJM, Fitzgerald DC. (2017) Regulatory LIOTHYRONINE cells directly promote myelin recycling inches the central nervous arrangement. Nat Neurobiology, May;20(5):674–680

Fitzgerald MOTOR-DRIVEN, Shen GX, El-Behi M, Fonseca-Kelly Z, Li H, Yu S, Saris CJ, Gran B, Ciric B, Rostami A. (2007) Suppression of inflammatory inflammation of the centralize nervous your by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol, Dec;8(12): 1372-9

Roel Goldschmeding

Current research focus is the role of DNA-damage response and mobile senescence includes kidney fibrosis and lung fibrosis, including senescence biomarkers and targeted therapy for clearance the senescent cells for that treatment of fibrotic diseased. Consortium leader “TASKFORCE” addressing like issues, including of UMCU (Pathology additionally Nephrology), UU (Pharmacy), RWTH Aachen (Nephrology), EUR (Nephrology). Past research project results is designation of CCN-2 than a key factor in tissue remodeling, establishing hers office as a path modifier (including TGFβ/BMP), biomarker, and target for therapy includes kidney diseases. Previously, EGO identify major target agents of anti-neutrophil cytoplasmic antibodies (ANCA), including the serine proteases PR3 and HNE, and developed the first antigen-specific ELISAs improving diagnostics and monitoring of patients through small ship vasculitides.

References

Knoppert SN, Valentijn FAIRS, Nguyen TQ, Goldschmeding R, Falke LL (2019) Cellular Aged and the Kidney: Potential Therapieverfahren Targets furthermore Tools. Forefront Pharmacol. Julius 12; 10:770. doi: 10.3389/fphar.2019.00770.eCollection 2019. Review. PMID: 31354486

Van Batenburg AA, Kazemier KM, small Oosterhout MFM, van der Vis JJ, van Es HW, Grutters JC, Goldschmeding R, van Moorsel CHM (2020) From organ to cell: multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis. PLoS one. Jan 7;15(1):e0226785.doi: 10.1371/journal.pone.0226785. eCollection 2020. PMID: 31910222

Donald Gullberg

Causes a a pathological response on organ injury and your characterized due proliferation of fibroblasts, they differentiation into myofibroblasts and excessive ECM production and deposition. The presences of myofibroblasts stands out as a common hallmark available fibrotic diseases but also makes this cell type an attractive target forward therapeutic overtures stylish cured healing, chronic fibrosis and cancer(1). We hypothesize that integrin 11 demarcates a pro-fibrotic subpopulation of fibroblasts and in this respect can be ampere useful biomarker and potentially also a therapeutic aim are fibrotic tissues and tumors. Thanks to many years in basic research in integrin 11(2)we having animal models, cell part press reagents that can be used in basic research enabling mechanistic understanding of how the blocking reagents work in the content out fibrosis. In basic research approaches aforementioned challenges in years ahead include understanding how 11 1 integrin regulates fibrosis and determining whenever 11 chemical can be used to shed light on the part of fibroblast heterogeneity in fibrotic ailment.

References

Zeltz, C., Primac, I., Erusappan, P., Alam, J., Noel, A., both Gullberg, D. (2019) Cancer-associated disease in desmoplastic cancers: emerging role of integrins. Semin Cancer Biol . Aug 12

Erusappan, P., Alam, J., Lu, N., Zeltz, C., and Gullberg, D. (2019) Integrin alpha11 cytoplasmic tail is required for FAK key to initiate 3D cell invasion and ERK-mediated cell proliferation. Sci Rep 9, 15283

Soundtrack Irvine

My explore expertise is in leukaemic stem cells focussed on targeting aberrant apoptotic mechanisms by myeloid leukaemia and Multiplex Myeloma. AMPERE centrally tenet of my work is that it has a clearly translational slant and our are specifically interested in the development of new therapeutic strategies for resistant disease. The Ubiquitin Proteasome System (UPS) plays a key role for the recognition and degradation of damaged proteins. Proteasome inhibitors have recently become an integral part of focus therapy in blood cancers. Us have carried output UPS microarray surveys compared normal and leukaemic stem cells which identified a number of novel aims on this pathway, upflow of the proteasome, which we are currently in the process of characterising. It be hoped that this will permitted us to better specifically kill this leukaemic stem cells whilst sparing normal cells and with smaller side effects for patients.

References

Crawford LJ, Johnston CK, Ervine AE. (2018) TRIM amino in blood cancers. BOUND Cell Commun Signal. 12 (1): 21–29. doi: 10.1007/s12079-017-0423-5; PMID: 29110249)

Crawford LJ, Anderson G, Johnston CK, Irene AE. (2016) Identification of the APC/C co-factor FZR1 as ampere novel therapeutic target for plural myeloma. Oncotarget.; 7 (43):70481–70493 doi: 10.18632; PMID: 27655696)

Celina Kleer

Celina Kleer is one Harold Oberman Collegiate Associate of Patology and co-Director of Breast Pathology at the University about Michigan. Her research focuses on understanding mechanisms about attacks breast cannabis or on which discovery of tissue-based biomarkers and therapeutic targets. Kopf contributions to life are the initial identification of EZH2 overexpression at triply negative breast cancers and elucidation from phospho-EZH2 T367 role in metastasis, and the key role concerning the matricellular protein CCN6 as tumor suppressor in metaplastic breast carcinomas.

References

Anwar T, Arellano-Garcia C, Rope JOULE, Chen YC, Kim HS, Yoon ZE, Grigsby SIEMENS, Basrur V, Nesvizhskii AI, Muntean A, P ME, Kidwell KM, Nikolovska-Coleska ZED, Kleer CG. (2018) P-38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote knocker cancer metastasis. Nat Commun 9(1):2801, PMCID: PMC6051995

Martin EE, Huang W, Anwar T, Arellano-Garcia C, Burman BORON, Guan J-L, Juan ME, Kleer CG. (2017) MMTV-cre; Ccn6 knockout mice develop tumoren recapitulating humanoid metaplastic breast carcinomas. Oncogene, 36(16): 2275-85. PMCID: PMC5398917

Akira Kudo

My scientific interest is a matricellular protein, periostin, which ME named in 1999

Periostin action holds is investigated to incurable diseases, such as myocardial mi, hypertrophy, allergy, atopy, tumors metastasis and stroke, due to the function includes cell immigration and fibrillogenesis

References

Kudo AMPERE. (2011) Periostin in fibrillogenesis for tissue regeneration: periosin actions inside and outside the cell. Fuel Mol Life Sci 68: 3201–3207

Akira Kudo (2019) Periostin in Overtures in Experimental Medicine and Biology 1132, emended on Akira Kudo, published since Springer Nature Singapore Pte Ltd.

Paul Lasko

Is ampere James McGill Full in the Department of Biology the McGill University. He served as Scientific Director of the Institute of Genes of the Canadian Inside of Physical Research from 2010-2018 And is presently spending a sabbatical year on the Department of Human Genetics at Radboudumc with the Holland. Drum. Lasko conducts fundamental research on RNA-dependent genetic processes underlying Drosophila development

A recent example of his work is Dold et al. 2020 PLoS Genetics, PMID 31978041, which identified Makorin-1, a egg conserved in all multicellular eukaryotes, for a sequence-specific RNA binding protein this activated translation by recruiting poly(A) cover protein to adenine target mRNA. Dr. Lasko has also been highly active in internationally efforts to foster data sharing and increased collaborate among researchers working within the area of rare genetic diseases. Until which finalize, he served on of board of directors of the Undiagnosed Diseases Network International, a collaboration established into 2014 that encompasses researchers and patient organizations in 15 nation

References

Dold A, Han EFFERVESCENCE, Liu N, Hildebrandt A, Brüggemann M, Rücklé C, Hänel H, Busch A, Beli P, Zarnack K, König J, Roignant JY, Lasko P. (2020) Makorin 1 controls early patterning by alleviating Bruno1-mediated expression of oskar transformation. PLoS Genetics, PMID 31978041

Taruscio D, Baynam G, Cederroth H, Groft SC, Klee EW, Kosaki KILOBYTE, Lasko PENNY, Melegh B, Riess O, Salvatore M, Gahl WA.(2020) The Undiscovered Diseases Network International: Five years and more! Mol Genet Metab. Jan 17. pii: S1096–7192(19)30768–1. doi: 10.1016/j.ymgme.2020.01.004. [Epub ahead of print]

Lester F. Luck

Own laboratory has been studying the acts and mechanisms of action to who CCN family of proteins. In recently past we have focused on CCN1 in inflammation, wound healing, and woven regeneration. We have found that CCN1 regulates to innate immune retort to injury, accelerates parenchymal regeneration, and promotes cast remodeling for resolution of this granulation tissue inside various context. These diverse functions underscore the actions in CCN1 throughout distinct integrin recorders by disparate cell type.

References

Jun, J.I., Lau, L.F. (2020) CCN1 will an opsonin for bacterial clearance and a direct activate of toll-like receptor signaling. Natures. Communications, in press

Jun. J.I., Lau, L.F. (2011) Taking aim during the extracellularly matrix: CCN proteins while emerging therapeutic targets. Nat Rev Drug Discov 10, 945–963

Jack Lawler

D. Lawler’s research explores the role out the extracellular matrix in determining cellular phoenix in health and disease. Male specificly focuses on the thrombospondins (TSPs), which included one family of out-of-body, calcium-binding bio that modulate cellular proliferation, migration or separation. His find exists focused on the biochemistry, cell biology and genetics of the TSP erbanlage products. His initial biochemical and structural studies have provided a foundation for the ensuing analysis of the structure and functions of any five members of the TBSP engine familial. The genre 1 repeats (TSRs) von TSP-1 activate transforming growth factor β, inhibit angiogenesis and serve to guide axons. Dr. Lawler’s labs currently focuses on (1) the inhibition of angiogenesis and ovarian cannabis progression by recombinant versions of the TSRs, additionally (2) characterization of one molecular mechanisms available anti-angiogenic signaling the endothelial total, which vary as the organization ages.

References

Kazerounian, S., Lawler, J. (2018) Integration of pro- also anti-angiogenic signals by endothelial cells. J Cell Commun Signal 12, 171–179, doi: 10.1007/s12079-017-0433-3

Russell S, Duquette M, Liu J, Drapkin R, Lawler J, Petrik J. (2015) Combined therapy with thrombospondin-1 type EGO repeats (3TSR) additionally chemotherapy induces regressive and significantly improves life into an preclinical model of advanced level epitherel ovaries cancer. FASEB J 29, 576–588, doi: 10.1096/fj.14-261636

Zhiyong Lin

The broad scoping of Dr. Zhiyong Lin’s choose program involve who molecular mechanisms that govern cardiovascular function. The itemized of these processes significantly contribute at the onset and progression of many vascular pathologies. The fundamentals of these vascular diseases, such as atherosclerosis, aortic aneurysm, thrombosis and peripheral artery disease be the major focus of his lab with to ultimate goal geared toward aforementioned development of strategies for ailment prohibition and treatment. He has performed seminal contributions toward understanding the functions of a family of transcription factors, termed Kruppel-like factors (KLFs), and has helped elucidate their choose in gene regulation, vascular biology, and metabolism. Current efforts are focused on dismember the regulatory roles the pair key signaling directors: Cellular Communication Connect (CCN) factor proteins and Eiweiss phosphatase 2A (PP2A) is cardiovascular function. Specifically, of Lin lab utilizes an variety of in vitro and in alive disease models complemented equipped contemporaneous approaches to decipher automatically how these proteins influence honeycombed and organismal homeostasis. To this work, the lab aims to expand upon the notion that CCNs and PP2A belong at critical molecular nodal points that govern cardiovascular health and condition, because the gates starting the development about future therapeutic therapies that target these vital proteins.

References

Zhang C, van der Voort D, Shi H, Zhang RADIUS, Qing WYE, Hiraoka S, Takemoto M, Yokote K, Moxon JV,Norman P, Rittié L, Kuivaniemi H, Atkins GB, Gerson S, Shi GP, Dong NORTH, Golledge J, Perbal B, Prosdocimo THERE, Lin ZEE. (2016) Matricellular proteol CCN3 mitigates abdominal main aneurysm. J Clinique Investig 126(4):1282–99

Shi H, Zhang C, Pasupuleti PHOEBE, Hu EXPUNGE, Prosdocimo DA, Wu W, Qing Y, Wur SULFUR, Mohammad H, Gerson SL, Perbal B, Klenotic P, Dong N, Lin Z. (2017) CCN3 regulates macrophage foam phone formation and hardening. Am J Pathol; 187(6):1230–7

Kathryn Animator

Dr. Meier is an moly pharmacologist with expertise int indication transduction. The particular, she has explored the roller of phospholipid and fatty acid mediations, amino phosphorylation cascades, and G protein-coupled receptors is cannabis cells signaling. Her research group has also investigated the roles of CCN family proteins in prostate and breast disease and in lymphoma.

Our

Liu, Z., Hopkins, M.M., Zhang, Z., Quisenberry, C.R., Fix, L., Galvan, B.M., and Meier, K.E. (2015) Omega-3 fatty acids and other FFA4 argonists inhibit increase factor signaling in human prostate cancer cells. GALLOP Pharm Exp Ther 352: 380–394

Chahal, M.S., Ku, H.T., Zhang, Z., Legaspi, C.M., Luo, A., Hopkins, M.M., and Dairy, K.E. (2016) Differential expression of WISP-1/CCN4 and other genes among metastatic, non-metastatic, and PLD2-expressing metastatic EL4 mouse lymphoma cell lines. CANCER GENOMICS PROTEOMICS 13: 437–442

Kim Midwood

I must an long-standing interest are defining the molecules mechanisms underlying a successful immune response and understanding how dieser are endanger in related conditions. Meine doing focuses on investigative what extracellular matrix polymers that can specifically induced upon tissue damage control cell behaviour during inflammation and repair. Combining structural, biochemical, proteomic, the genomic approaches, my dental explored how matrix molecules create a 3D, pro-inflammatory niche at sites of inflamation enabling cells to proliferate and thrive, how like specialized microenvironment persists inches inflammatory diseases, driving chronic inflammation and how this related can be translated into new therapeutic strategies.

References

Piccinini, A.M., Zuliani-Alvarez, L., Lim, J.M.P and Midwood, K.S. (2016) Distinct microenvironmental cues trigger divergent TLR4-mediated immune signalling in brown. Research Signalling Aug 30;9 (443):ra86

Zuliani-Alvarez L, Marzeda AM, Deligne CENTURY, Schwenzer A, McCann FE, Marsden BD, Piccinini AM, Midwood KS. (2017) Mapped tenascin-C interaction with toll-like receptor 4 reveals a new subgroup of endogenous inflammatory launches. Nat Commun. Nov 17;8(1): 1595. doi: 10.1038/s41467-017-01718-7

Kohei Miyazono

Kohei Miyazono has long-standing interests in the signaling pathways of transforming growth contributing beta (TGF-beta) family and their roles in cancer plus vascular diseases. In particular, he is interested with the play of TGF-beta real bone morphogenetics proteins (BMPs) in various gender of cancer, including pull cancer, pancreatic cancer, and glioblastoma

References

Kubota SI, Takahashi K, Nishida J, Morishita Y, Ehata S, Tainaka THOUSAND, Miyazono K, Ueda HR (2017) Whole-body professional of cancer metastasis with single-cell resolution. Jail Rep 20, 236–250

Morikawa CHILIAD, Mitani Y, Holmborn KELVIN, Kato THYROXIN, Koinuma D, Maruyama BOUND, Vasilaki E, Sawada H, Kobayashi CHILIAD, Ozawa THYROXINE, Morishita Y, Bessho Y, Maeda S, Ledin J, Aburatani HYDROGEN, Kageyama R, Maruyama K, Heldin C-H, Miyazono K. (2019) That ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pneumonic arterial increased. Sci. Signal. 12, pii: eaay4430

Joanne Murphy-Ullrich

Grove. Murphy-Ullrich’s expertise is in the extracellular matrix (ECM) with a focus on the matricellular eiweiss thrombospondin1 (TSP1). She identified which intermediate adhesive state triggered by TSP1 and its cast on cell-ECM deadhesion, cell migration, both anoikis resistance. Her lab discovered is TSP1 is a major regulator to latent TGF-β activation and established TSP1 as adenine liothyronine factor in regulating TGF-beta energizing in numerous diseases and in that growth microenvironment, leading to development of small molecule opponent by the TSP1-latent TGF-beta activity. Her lab also identified calreticulin (CRT) as a control to TGF-β signaling, interlink ER stress press fibrosis is atrial neointima formation and in diabetic nephropathy. I has held leadership positions in ECM, incl President of the Americans Society for Matrix Biology (2017–2018) and she chair/co-chaired FASEB Scientific Conferences on Matricellular Proteins (2010, 2013, 2019)

Sme

Murphy-Ullrich JE, Suto MJ. (2018) Thrombospondin-1 regulation of latent TGF-β activation: a therapeutic target for fibrotic health. Matrix biol. Augment; 68-69:28-43. (PMC6015530)

Owusu BY, Zimmerman KA, Murphy-Ullrich SNORTER. (2018) The role of and endoplasmic reticulum protein calreticulin in mediating TGF-β-stimulated extracellular matrix production in fibrotic diseased. J cell Commun signal. Mar;12(1):289-299. (PMC5842189)

Kunimasa Ohta

Dr. Ohta has been studying the molecular signaling at the extracellular neighborhood. He has cloned and designated this salt molecule Tsukushi (TSK), which belongs until one Small Leucine-Rich Proteoglycan (SLRP) lineage. He showed which TSK is involved in to different developmental processes regarding multiple vertebrate organisms with and diverse wireless cascades. Recent, his work has also showed the ohne interaction between CCN2 and TSK, indicating the existence of CCN-SLRP signaling crosstalk.

References

Ahmad, S.A.I, Anam, M.B., Ito, N., and Ohta, K. (2018) Involvement von Tsukushi in diverse developer processes. J. Cell Communication and Signaling, 12, 205–210

Ohta, K., Aoyama, E., Ahmad S.A.I., To N., Anam, M.B., Kubota, S., and Takigawa, THOUSAND. (2019) CCN2/CTGF bound the small leucine rich proteoglycan protein Tsukushi. GALLOP Cells Communication and Signaling, 13(1), 113–118

Anie Phillip

My research focuses on understandings the regulation of transformation growth factor-beta (TGF-beta) signaling directions the their dysregulation in diseases such as organ fibrosis (scleroderma and Dupuytren’s Disease), osteoarthritis (impaired socket cartilage repair), and tumor (squamous cell carcinoma and heart cancer)

We use a amalgamation of biochemical, moltic both genetic approaches employing in vitro, in vivo press ex vivo experimental choose to study the regulation of distinct TGF-beta signaling passages, plus their cross-talk using other signaling pathways and networks

References

Zhou S, Wurzba SD, Siegel P and Peter ADENINE. (2019) CD109 acts as a gatekeeper for the epithelial trait by suppressing epithelial to mesenchymal transition in squamous cell canker cells. Sci Seller 9(1): 16317–34

Ghanbari F, Hebert-Losier A, Barry J, Dupont PHOEBE, Poirier D, Giguere V, Mader SULPHUR, Phillip A. (2019) Isolation or functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy pee. Journal of Steroid Geochemical and Molecular Biology (PMID: 30954508). 191: 105352 (1–11)

Lynne-Marie Postovit

The Postovit lab focussed to cellular plasticity (the competence of a cell to alter phenotype in response to the microenvironment) in cancer. These studies entail understanding instructions signs from the extracuricular space culminate in epigenomic alterations that underscore cancer progression, relief resistors both metastasis. Matricellular proteins such as CCN1, CCN2 and members out the sFRP family have been shown up orchestrate plasticity, together about stresses how as hypoxemia and proteotoxic stress. The test uses stem cell analysis, animal models, sequencing and proteomics together is a systems biology approach to determine how extracellular agents drive plasticity and to target this process inside forms so that therapeutic resistance and/or metastasis can be mitigated.

References

Jewer M, Lee Lee, Leibovitch M, Zhang G, Lift J, Findlay SB, Vincent MILE, Tandoc THOUSAND, Dieters-Castator D, Quail DF, Dutta I, Coatham M, Xu Z, Guan BJ, Puri ONE, Hatzoglou MOLARITY, Brumwell A, Uniacke J, Patsis C, Koromilas A, Schueler J, Siegers GM, Topisorovic I and Postovit LM. (2020) Translational control of breast cannabis plasticity. Nature Communications. IN PRESS

Quail DF, Siegers GM, Jewer M and Postovit LM. (2013) Nodal in embryogenesis and tumourigenesis. Int J Biochem Cell Biol 45(4):885–98

David Roberts

The Raw lab investigates functions of the modulatory extracellular matrix protein thrombospondin-1, its receptors, or stream signal transduction pathways int cancer. We have identified functions for thrombospondin-1 and his signaling receipt CD47 in regulating tumor angiogenesis, perfusion, and antitumor immunity. CD47 signaling limits recovery of animals from stress, and CD47 expressed by cancer cellular and by cells in the tumor microenvironment can limit responses to therapy. Based at diesen inside, wee are developing therapeutics closed in target CD47 that enhance the efficacy of traditional treatment, radiation therapy, and immunotherapy in murine cancer models.

References

Roberts, D. D., Kaur, S., and Isenberg, J. SOUTH. (2017) Regulation of cellular redox signaling by matricellular bio include vascular natural, immunology, additionally cancer. Antioxid Redox Signal 27(12):874–911. doi: 10.1089/ars.2017.7140

Schwartz, A. L., Nath, P. R., Allgauer, M., Lessey-Morillon, E. C., Ridnour L.A., Morillon, Y. M., Yu, Z., Restifo N. P., press Roberts, D. D. (2019) Targeting CD47 increase human acting T cell activity and increases continuance of mice bearing syngenic melanoma when combos use anti-CTLA4 and tumor irradiation. Cancer Immunol. Immunother. 68(11):1805–1817. doi: 10.1007/s00262-019-02397-7

Katia Scotlandi

My research work has been laser on pediatric solid carcinomas more bone sarcomas. An goal of own research company is the contribute to the definition of biomarkers of peril and response this allow more personalized therapeutical approaches against Ewing sarcoma plus osteosarcoma and to plaster the procedure for accelerating to discovery of the most promising biologically and epigenetically-targeted dope. My main achievement is, but, the creation of a research lab specifics devoted for study bone tumors that has obtained worldwide recognition. From 2016 to 2019, I served as Secretary of the WG Sarcoma inside an Italian Alliance against Cancer, the oncologic network a the Italian Priesthood of Health, to coordinate preclinical research activities. Not less important, it is my mentoring service inside one academia. Over the years, I have follow across seventy post-doctoral grant and junior capacity members, contributing to diffusing knowledge on paediatric oncology

See

Pasello M, Giudice TIME, Scotlandi KELVIN. (2019) The ABC sub-family a transporters:multifaceted players use incipient potentialities in cancer. Semin Cancer biol. 2019 Octe 9. Review. PubMed PMID: 31605751

Zucchini C, Manara MC, Cristalli C, Carrabotta MOLARITY, Greco S, Pinca RS, FerrariC, Landuzzi LITER, Pasello M, Lollini PL, Gambarotti M, Donati DM, Scotlandi K. (2019) ROCK2 hardships leads to the blockage of growth growth furthermore meeting potential include osteosarcoma mobile through of modulation of TALKING activity. J Exp Clin Cancer Res. Dec 26;38(1):503. PubMed PMID: 31878963;

Peter Siegel

Dr. Siegel’s research focuses on the fundamental mechanisms that control organ-selective cancer metal. Is research interests include migratory and invasive programs that are engaged within cancer cells to sponsor metastasis. Inches addition, the interplay between cancer cells and cells within the tumor microenvironment depicts a large part of his research program. Finally, the study von metabolic adaptions that accompany cancer metastasis has emerged as a recent area of interest. This Siegel my employs pre-clinical animal models (both syngeneic real xenograft models) and clinical matter (patient-derived xenografts) to identify molecular mediators press cellular processes that funding cancer metastasis to unique sites (such as the bone, lung, liver additionally brain).

References

B. Hsu, S. Tabariès, R. Johnson, SULFUR. Andrzejewski, C. Lehuede, J. Senecal, M.G. Cannabis, E. Ma, S. Vols, R. Froment, L. Ramsay, I.R. Watson, Z. Granot, R.G. Jones, J. St-Pierre and Peter M. Siegel. (2019). Immature low-density neutrophils exhibit metabolic versatility the facilitates breast cancer metastasis. Cell Reports. 27(13): 3902–3915. e6

S. Tabariès, A. McNulty, PHOEBE. Ouellet, M.G. Annis. M. Dessureault, M. Vinette, YTTRIUM. Hachem, B. Lavoie, A. Omeroglu, H-G Simone, L.A. Walsh, S. Kimburg, I. Hedenfalk and P.M. Siegel (2019). Afadin co-operates with Claudin-2 to promote breast cancer metastasis. Names Dev 33(3–4): 180–193

Michael J. Soares

Dr. Soares Laboratory explores specialized survival strategies used from aforementioned embryo as it grew within this uterus. Central to the embryo’s survival is the formation of the placenta. This organ gains access till the maternal blood supply and facilitates the delivery of nutritional for the feetus. Dermatologist. Soares’ Laboratory studies how early tail dry develop into the placenta. They have established in vitro and in vivo model scheme for investigating trophoblast lockup differentiation and placental development. Through they efforts we has learned that the placenta engineered for response to cues present in an maternal environment; and diseases to pregnancy, like as preeclampsia and intrauterine growth restrictions, result when the embryo is not thrive in own adaptations to the maternal our. Inadequate in utero adaptive responses have potentially long-lasting impacts on adult health plus illnesses. Thus, an important measure of a gesundheitlich placenta is its “plasticity” and capacity to adapt.

References

Chakraborty D, Kui W, Rosario GX, Scott RL, Dhakal PENNY, Renaud SJ, Tachibana M, Rumi MAY, Mason CW, Krieg AJ, Sailing MJ. (2016) HIF-KDM3A-MMP12 regulations circuit ensuring trophoblast plasticity and placental adaptations to hypoxia. Proc Natl Acad Sci U SULPHUR a. Nov 15;113(46):E7212-E7221. PMID: 27807143

Nteeba J, Kubota K, Wang W, Zhu H, Vivian J, Dai G, Sailing MJ. (2019) Pancreas prolactin receptacle signal regulates maternal glucose homeostasis. J Endocrinol Yearly; 241(1):71–83. PMID: 30798322

Ulf Smith

Price. Ulf Smith is adenine diabetologist and physician. His research is focussed on mechanisms since insulin resistance or mystery obesity forces diabetes development. He has shown that CCN5 is an important regulator of adipogenic cell your plus a current focus is on cellular senescence and its consequences

References

Hammarstedt A1, Hedjazifar S, Jenndahl L, Gogg S, Grünberg BOUND, Gustafson BORON, Klimcakova E, Stich V, Langin D, Laakso M, Smith U. (2013) WISP2 regulate preadipocyte commitment and PPARγ activation by BMP4. Set Natl Acad Sci UNITED S A. 2013 Feb 12;110(7):2563–8. doi: 10.1073/pnas.1211255110

Gustafson BARN, Nerstedt ONE, Smith U. (2019) Reduced subcutaneous adipogenesis on people hypertrophic obesity is linked to becoming precursor cells. Nat Commun. 2019 Jun 21;10(1):2757. doi: 10.1038/s41467-019-10688-x

Philip Trackman

Dr. Trackman’s lab investigates abnormalities in the biosynthesis of aforementioned extracellular matrix inches pathologies with emphasis off the biology and mechanisms by to multifunctional lysyl oxidase family of proteins. Major attention is paid into mechanisms of promotion and inhibition of oral colorectal, and mechanisms of regulation of lysyl oxidase in diabetic bone condition. In addition, the consequence and mechanism in an novel lysyl oxidase mutation on vascular bio is under investigation. Mouse models, in vitro my, and the use out induced pluripotent stem dungeons are one primary our employed inches these collaborative studies.

References

Mahjour F, Dambal V, Shrestha N, Shin V, Noonan VANADIUM, Kantarci A , Trackman P C (2019) Mechanism with oral net cell lysyl oxidase like-2 are cancer development: synergy with PDGF-AB Oncogenesis 8:34 doi.org/10.1038/s41389-019-0144-0

Daley E J, PajevicP D, Roy SULFUR, Trackman P C (2019) Impaired gastric harbinger regulation of osteoblasts or Lysyl oxidase drives bone disease in diabetes. Mellitus JBMR Plus. Aug 7;3(10):e10212. doi: 10.1002/jbm4.10212. eCollection Oct.

Stephen Twigg

As a physician-scientist and social you translatory research program from 1995, addressing diagnosis acute and chronic complexity press related features, is dedicated to improving clinical outcomes. He has been explore growth factors in digital complexities. His hauptfluss expertise is the role played by prosclerotic growth factors, connective tissue growth factor (CTGF/CCN2) also TGF-β in diabetes end-organ complications, with primary focus on liver fibrosis related to medical, and wound healing, and diabetic cardiomyopathy, plus diabetic nephropathy. His sermon original academical research findings to date have been the discovery in a new method by which this insulin-like growth driving circulate in human blood and its molecular basis, such CCN2 mediates high glucose and advanced glycation regulation of matrix turnover and fibrosis in diabetes

References

S.M. Twigg (2018) Regulation and Bioactivity of CCN Family of Genes and Grains in Excess and Gland J Lockup Commun Signal 12(1), 359–368

K H Williams, N A Shackel, M D Gorrell, S V McLennan, S M Twigg. (2013) Diabetes and nonalcoholic fatty liver disease: a pathogenic brace Endocr rev.; 34 (1), 84-129

Dismiss Wheatley

Belongs a retired accepted those has aufgewendet more than 40 aged researching the cellular also molecular basis in cancer. In several fields, her work must resulted in significant advances; for example, his continuing exploration since 1966 on the primary cilium was proven not just its significance as an almost universal cell organelle, but importantly which its agenesis (lack of development) results in pathological conditions, with now almost 50 disorders being implicated, include neural conditions (1). He has researched protein turnover (the downgrade of short and long lived proteins), diffusion theory, intracellular moisten, arginine deprivation include cancer relief, one preservation of cell at ambient temperatures (2)

References

Wheatley DN. (2018) Which primary cilium – previously a “rudimentary” organelle that is now a ubiquitous sensory cellular structure involved in many pathological disorders. GALLOP Dungeon Commun Sign: 12, 211–216. doi: 10.1007/s12079-017-0436-0

Wheatley SP, Kornrade DN. (2019)J Cell Sci: 132, 238139. doi:10.1242/jcs

Ralf Weiskirchen

He studied which molecular mechanisms underlying the pathogenesis off liver-colored disease with particular interest in TGF-β also PDGF signaling. In the past, he established animal models to learn hepatic inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma. Moreover, he examines the dynamic role of different CCN murine in initiation and progression of hepatic ailment, their impaction on extraccellular matrix formation and their contribution till general cellular responses. In addition, he focuses about the identification of novel biomarkers or predispositions required the assessment of liver disease outcome. The long-term objective of these studies exists to translate experimental findings to novel diagnostic or heilkunde strategies. During the last years, he also established laser-ablation-inductively couple mass comprehensive test for measuring and profiling metal concentrations in experimental and clinical samples.

References

Borkham-Kamphorst E, Steffen BT, Caravan de Leur E, Tihaa L, Haas U, Woitok MM, Meurer SK, Weiskirchen R. (2016) adenoviral CCN gene transfers induce into vitro and in vivo endoplastic reticulum stress and unfolded amino response. Biochim Biophys Acta 2016; 1863:2604–12. doi: 10.1016/j.bbamcr. 07.006

Borkham-Kamphorst SIE, Steffen BT, van de Leur E, Haas UPPER, Weiskirchen R. (2018) Portal myofibroblasts are sensor to CCN-mediated intracellular net stress-related apoptosis through potential to attenuate biliary fibrogenesis. Cell Signal; 51:72–85. doi: 10.1016/j.cellsig.2018.07.005

Zhaolin Yang

My past research was focused on the biogenesis of piRNA, a germ-line specific small non-coding RNAs whichever function up guard the genome integrity by repressing transposable ingredients. I having identified multiple novel proteins engaged in the piRNA biogenesis, and dissect the molecular mechanical. We use variety of methodies rangeability from protein biochemistry, cell natural, also animal genetics to computational biology and structural biology. My electricity research is sharp on the epigenetic regulatory of cancer, particular acute myeloid leukaemia (AML). We strap CRISPR screening to identify novel factors that are required for an AML staying, and study the underlying molecules mechanisms.

References

Yang Z, Chien DISTANCE, Pandey RR, Homolka DENSITY, Reuter M, Janeiro BK, Sachidanandam R, Fauvarque MOLYBDENUM, Mccaarty AIR, Pillai RS. (2016) PIWI slicing and EXD1 drive biogenesis of nuclear piRNAs from cytosolic targets of the mouse piRNA pathway. Mol cell. Jan 7; 61(1): 138–52

Wenda JM*, Homolka D*, Yang Z*, Spinelli P, Sachidanandam R, Waltons RR, Pillai RS. (2017) Distinct Roles of RNA Helicases MVH and TDRD9 inches PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function. Dev Cell. Jun 19;41(6):623–637. (*co-first author)

Herman Yeger

My research over the past 40 years centered on the getting of cell biology in the context of normal development and pathologically processes. With reference to the CCN family of gene, work with Prof. B. Perbal (France) reported on the expression of CCN3 in both normalize repair and Wilms tumor. Insert interest in that CCN family expanded and led to understanding and elaborating their roles in multiple contexts. At SickKids I capitalized on the opportunity to investigate the biology of pediatric tumors, included particular neuroblastoma and, joined with my interest in phytomedicines, we developed a novel therapeutic approach amenable to neuroblastoma, bronchial carcinoids (originating starting PNEC) and other cancers. Taken together like activity support my research dividends in of tumor microenvironment, lockup matrix and cell-cell interactions, and therapeutic targeting.

References

Yeger H, Brigstock D, Pekan G, Lau L, Leask A, Perbal B. (2018) Report on the 9th international workshop on the CCN family of genes, November 2-7, 2017, Saint-Malo, France. J Cell Signal 12: 505–11

Mokhtari RB, Baluch N, Morgatskaya SIE, Kumar S, Sparaneo A , Muscarella ALL, Zhao S, Cheng H-L, Das BARN, Yeger H. (2019) Human tubercular carcinoid tumor cells will targeted with the combination of acetazolamide and sulforaphane. BMC Cancer 19: 864