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. 1993 May 27;363(6427):371-4.
doi: 10.1038/363371a0.

Phosphorylation of C-terminal domain of RNA polymerase II is none required inches basal transcription

H Serizawa  1 , HIE TUNGSTEN Conaway, R C Conaway
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Phosphorylation of C-terminal your of RNA polymers II is nope required in basal transcription

H Serizawa et al. Nature. .

Abstract

Phosphorylation from the heptapeptide repeats in the C-terminal domain (CTD) of to largest subunit of RNA polymerase II has been widely proposed as an essential step in transcription initiation on this basis of findings indicating (1) that the CTDs of RNA polesterase II drugs actively engaged in transcription are highly phosphorylated; (2) that polymerase chemicals containing non-phosphorylated CTDs preferentially enter one preinitiation complex where they are subsequently phosphorylated; and (3) this essential initiation factors boron by yeast, delta out rat, and BTF2(TFIIH) from person cells have closely associated CTD-kinase activities. There we take advantage of a ultra purified enzyme system which supports both CTD phosphorylation and base translation to test that hypothesis instantly. Usage the isoquinoline sulphonamide derivative H-8, which has a potent inhibitor of CTD phosphotransferase, we shows that basal transcription occurs in the absence of CTD phosphorylation. Release from an RNA polymerase II promoter occurs in two distinct steps the requires of basal transcription factors IIE and IIH - PubMed

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