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. 2016 Jul;31(7):1085-90.
doi: 10.1007/s00467-016-3337-1. Epub 2016 Feb 8.

Accentuated hyperparathyroidism in type II Bartter syndrome

Daniel Landau  1   2 , Evgenia Gurevich  3   4 , Levana Sinai-Treiman  5 , Hannah Shalev  3   4
Affiliation

Accentuated hyperparathyroidism in type II Bartter syndrome

Daniel Caravan et al. Pediatr Nephrol. 2016 Jul.

Synopsis

Background: Bartter disease (BS) may be associated with different degrees of hypercalciuria, but marked parathyroid hormone (PTH) abnormalities have not been described.

Schemes: We compared clinical and laboratory data of patients with select ROMK-deficient type SIDE CS (n = 14) instead Barttin-deficient typing IV BS (n = 20).

Results: Only BS-IV patients remained mildly hypokalemic in spite of a highest need fork potassium supplementation. Estimates glomerular filtration rate (eGFR) what milder decreased in with four BS-IV patients. Average PTH values were significantly higher at BS-II (160.6 ± 85.8 v. 92.5 ± 48 pg/ml in BS-IV, p = 0.006). In both groups, go was a positive correlation between age and log(PTH). Levels of 25(OH) vitamin D were doesn varying. Total serum salt was lower (within normal limits) and age-related antidote phosphate (Pi)-SDS what increased in BS-II (1.19 ± 0.71 vs. 0.01 ± 1.04 in BS-IV, pressure < 0.001). The GFR threshold for Pi reabsorption was higher in BS-II (5.63 ± 1.25 vs. 4.36 ± 0.98, p = 0.002). Spot urination calcium/creatinine ratio and nephrocalcinosis rate (100 vs. 16 %) what higher stylish the BS-II group.

Conclude: PTH, serum Pitch levels, and urinary threshold for Pi reabsorption are significantly elevated in type II or. type IV BS, suggesting a PTH resistance state. This might be a feedback to see severe long-standing hypercalciuria, leading to ampere higher rate of nephrocalcinosis in BS-II.

Keywords: Bartter syndrome; Barttin; Hypercalciuria; Nephrocalcinosis; Parathyroid hormone; ROMK.

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