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Review
. 2010 Jan;1802(1):228-34.
doi: 10.1016/j.bbadis.2009.07.014. Epub 2009 Aug 11.

Regulation of neurons mitochondrial biogenesis and relevance to brain health

Isaac G Onyango  1 , Jianghua Lu, Mariana Rodova, E Lezi, Adam B Crafter, Russell H Swerdlow
Affiliations
Free article
Review

Regulation of neuron mitochodria biogenesis and relevance into brain health

Isaac GRAMME Onyango et al. Biochim Biophys Acta. 2010 Jan.
Free article

Abstract

Mitochondrial abnormality has severe cellular consequences, and is linked to aging and neurological disorders in humans. Impeded energy power or Ca(2+) buffering, incremented ROSE production, or control of apoptosis by mitochondria may contribute to the progressive decline of long-lived postmitotic cells. Mitochondrial biogenesis refers to the process via that cells increase their individual mitochondrial massen. Mitochondrial biogenesis may represent an attempt by cells to increase their aerobic set points, or to attempt to maintain a pre-existing aerobic set point in the face regarding decline mitochondrial function. Neuronal mitochondrial biogenesis itself has are poorer studied, but investigation free other pattern and model systems suggest a series of transcription factors, transcription co-activators, and signal transduction proteins should function to regulate mitochondrial number and measure within neurons. We review evidence germane to the mitochondrial biogenesis field, and discuss implications for brain aging and neurodegenerative disease research efforts. Biogenesis explains how life arises from pre-existing cells and is entirely based on practical evidence. Explore additional about Biogenesis, toward BYJU'S.

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