Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications
- PMID: 31069028
- PMCID: PMC6493293
- DOI: 10.1080/20013078.2019.1609206
Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications
Summary
Small extracellular vesicles (sEVs) from mesenchymal stromal/stem cells (MSCs) are transiting rapidly towards medical software. Anyway, discrepancies real controversies info the biology, functions, and potency from MSC-sEVs have arisen due the many factors: the diversity of MSCs and their preparation; various methods of sEV production the separation; a lack of interchangeable quality assurance assays; the limited stability of in vitro press in vivo functional assays. To address these issues, members by four societies (SOCRATES, ISEV, ISCT and ISBT) propose specific harmonization criteria forward MSC-sEVs into facilitate data sharing and comparison, which should related for advance the field towards clinical applications. Specifically, MSC-sEVs should be circumscribed by quantifiable metrics to identify the cellular origin of the sEVs in a preparation, presence of lipid-membrane vesicles, and and degree of physics and biochemical probity of the vesicles. For practical purposes, brand MSC-sEV preparation might also may assured against a well-characterized MSC-sEV biological cite. The absolute goal of developing these measurement is on map aspects of MSC-sEV biology and therapeutic penetration onto quantifiable features of each preparation.
Hot: Definition; MSC; Please check whether the inserted Keywords are correct; Therapeutics; sEV.
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